Events
Greenville is the site of the annual Agape Music Festival, a Christian music festival. It also plays host to the World Powered Parachute Championships as "Chute-Out on the Prairie."
Greenville conducts the Bond County Fair every August; 2007's events took place August 1-7. In 2008, the Vietnam Veterans' Memorial Moving Wall will be visiting Greenville to coincide with the fair activities.

Education
In addition to Greenville College, Greenville is home to Bond County Community Unit #2 High School (usually known as Greenville High School), home of the Comets, who in 2007 made it to the final four in the IHSA class 3A state football playoffs and fell to the Columbia Eagles 39-40. Students from the neighboring towns of Pocahontas and Sorento attend high school in Greenville.
Greenville Junior High, home of the Bluejays, and Greenville Elementary School, home of the Rockets, round out Greenville's local schools. As of the 2006 school year, Greenville Elementary was selected as a NASA Explorer school.
From 2004 to 2007, Greenville also had a private Christian school, Greenville Christian Academy, run by Smith Grove Baptist Church. However, the school closed due to lack of enrollment in May 2007. Other nearby private school alternatives are Vandalia Christian Academy and Mater Dei in Breese.

Notable residents
Nobel Prize-winning biochemist Edwin G. Krebs lived in Greenville from the age of 6 to 15. Noted astronomer Alfred Harrison Joy was a prominent member of Greenville society and the son of the former Greenville mayor and merchant F.P. Joy.
Greenville is the birthplace of the sixth governor of Colorado, Job Adams Cooper. Cooper married his wife, the daughter of a prominent local preacher, in Greenville.
Anti-boxing activist Manuel Velazquez retired in Greenville and died in 1994.
The Christian band Jars of Clay went to school and formed at Greenville College, which is noted for its Contemporary Christian music program. The popular alternative band Augustana also began at Greenville College.
Noted environmental activist Howard Zahniser went to Greenville College and later wrote the Wilderness Act of 1964. He taught English at Greenville High School.
Local resident Dr. Robert E. "Ish" Smith served as the president of the International Baseball Federation for 12 years (1981 to 1993) and the United States Baseball Federation for nine years (1981 to 1990). After he retired from the presidency of the IBA, he served as President of Greenville College.
Country music star Gretchen Wilson is a native of the nearby town of Pocahontas and attended Greenville High School but did not graduate.
CNET Executive Editor Tom Merritt was born in Greenville.